FIG 6.
ClfA sequesters SAR114/MEDI4893* BiSAb in i.n. lethal pneumonia. C57/B6 mice (n = 10) were passively immunized i.p. with BiS2, BiS3, MEDI4893*, or the SAR114-MEDI4893* MAb combination at the indicated concentrations and i.n. infected 24 h later with 1.5e6 CFU of SF8300 (A) or the SF8300 ΔclfA isogenic mutant (B). Survival was monitored for 6 days. Results were analyzed with a log rank (Mantel-Cox) test. Results compared to those for c-IgG were considered statistically different at a P value of <0.05. Data are representative of three independent experiments.