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SAR114-MEDI4893* MAb combination strain coverage protection in lethal bacteremia
| Strain | ST | Protection against lethal bacteremia bya: |
||
|---|---|---|---|---|
| SAR114 (15 mg/kg) | MEDI4893* (15 mg/kg) | Combination MAb (7.5 mg/kg each) | ||
| NRS123 | 1 | + | − | + |
| ARC2784 | 188 | + | + | + |
| ARC635 | 5 | + | + | + |
| NRS387 | 5 | + | + | + |
| SF8300 | 8 | + | + | + |
| NRS384 | 8 | − | − | + |
| 3049057 | 8 | − | − | + |
| 3049088 | 30 | + | − | + |
| 3049114 | 30 | + | − | + |
A plus sign indicates significantly different from c-IgG (15 mg/kg) by log rank (Mantel-Cox) test.
