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. 2017 Jul 25;61(8):e00751-17. doi: 10.1128/AAC.00751-17

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Copyright © 2017 Srivastava et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Linezolid kill curves for sterilizing activity and acquired drug resistance. (A) Time-kill curves for the once-daily dosing schedule show that an AUC_0–24/MIC ratio of ≥73.6 killed to levels below day 0 bacterial burden (stasis line). (B) Time-kill curves with the twice-daily dosing schedule demonstrate bacterial burden below limits of detection in hollow fiber cartridges at high AUC_0–24/MIC ratios. (C) The relationship between exposure and drug-resistant subpopulation is a system of changing U-shaped curves. The best fit for this quadratic function was with the percentage of time that the concentration persists above the MIC (%T_MIC). A %T_MIC of 100 suppressed the linezolid-resistant subpopulation.