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Target attainment probability of different linezolid doses in clinical trial simulations. (A) Target attainment probabilities of the linezolid 150-mg once-daily dose. (B) The target attainment probability of the 300-mg daily dose was >90% until an MIC of 1 mg/liter. (C) The dose of 600 mg per day performed well at all observed MICs, even with the MIC data set with the most leftward skew. (D) The 1,200-mg daily dose did not improve much on the 600-mg-per-day dose.
