TABLE 1.

Akaike information criterion scores for microbial kill and acquired drug resistance^c

Day	Microbial kill			ADR
	AUC/MIC	Cmax/MIC	%TMIC	AUC/MIC	Cmax/MIC	%TMIC
7	−13	−13	NCa	−19	−19	−18
14	−3	−3	27	−11	−6	−4
21	4	4	−4	11	19	16
28	−1	−3	11	−1	11	7
35	−1	20	12	−2	8	0.1
42	17	23	13	NCb	NCb	NCb
49	23	29	8	−5	−6	−14
56	22	28	2	10	9	−19

^aNC, nonconvergence.

^bDrug-resistant subpopulation was below limits of detection on day 42.

^cBoldface values indicate the lowest Akaike information criteria score, and therefore PK/PD index linked to microbial effect of either microbial kill or acquired drug resistance (ADR).