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Pharmacokinetic parameter estimates as observed in patients and those from our simulations
| Parameter | Value observed in: |
|||
|---|---|---|---|---|
| 435 patients |
10,000-patient simulation |
|||
| Mean | IIVa (%) | Mean | Range | |
| Clearance (liters/h) | 6.0 | 46.6 | 5.8 | 2.03–18.2 |
| Vol (liters) | 54.53 | 25.9 | 54.4 | 42.1–69.9 |
| Absorption constant (h−1) | 0.58 | 40 | 0.59 | 0.1–9.7 |
IIV, interindividual variability as percent coefficient of variation.
