Yearly rates of ST131 clades and subclades in Japanese ESBL-producing E. coli. Rates of ST131 and subclades C1-M27 and C2 increased yearly (P < 0.001 each). In 2014, the rates of clades A and B and subclades C1-M27, C1-non-M27, and C2 were 3, 1, 31, 15, and 24%, respectively.