TABLE 4.

Ratio of unbound protein (fAUC_0–24) relative to the MIC of LFX (n = 20)

Patient	Cmax (mg/liter)	MIC (mg/liter)	Cmax/MIC	AUC0–24 (mg·h/liter)	fAUC0–24/MICa	fAUC0–24/MICb
1	16.2	0.25	64.8	139.6	362.96	474.64
2	13.1	0.5	26.2	159.6	207.48	271.32
3	14	0.25	56	153.6	399.36	522.24
4	8.7	0.25	34.8	114.4	297.44	388.96
5	9.2	1	9.2	99.82	64.88	84.85
6	13.1	0.5	26.2	119.1	154.83	202.47
7	10.2	0.25	40.8	82.66	214.92	281.04
8	4.3	1	4.3	31.35	20.38	26.65
9	10.8	0.5	21.6	85.38	110.99	145.15
10	6.8	0.5	13.6	79.77	103.70	135.61
11	11.1	0.25	44.4	111.3	289.38	378.96
12	9.8	0.5	19.6	90.85	118.10	154.45
13	7.6	0.5	15.2	83.16	108.11	141.37
14	12.3	2	6.15	126.5	41.11	53.76
15	7.1	0.5	14.2	68.76	89.39	116.89
16	9.9	2	4.95	156.9	50.99	66.68
17	12.5	0.25	50	97.81	254.31	332.55
18	7.6	≥2	–c	85.44	–	–
19	9.2	≥2	–	97.78	–	–
20	12	≥2	–	123.2	–	–

^aAs determined using a protein unbound fraction of 65%.

^bAs determined using a protein unbound fraction of 85%.

^c–, three patients had MICs of >2 mg/ml and were not included.