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The active site of VIM-2 and of TMB-1 with inhibitor 2b in the active site. (A and B) Calculated electrostatic surface potential of VIM-2_2b (A) (40) and modeled inhibitor 2b (the new TMB-1; the crystal structure) (B). The two active site zinc ions are shown as spheres. The red areas represent negatively charged surface areas, and the blue areas represent positively charged surface areas. The black circles show the R2 binding site.
