FIG 4.

Effects of combinations of atorvastatin (ATV) with several bisphosphonates on survival of mice infected with tachyzoites. (A) Groups of mice were either untreated or treated with zoledronate alone (0.01 mg/kg/day) or the combination of zoledronate (0.01 mg/kg/day) and atorvastatin (1.25 mg/kg/day). (B) Survival at 30 days of mice treated with atorvastatin (1.25 mg/kg/day) or zoledronate (0.01 mg/kg/day) alone or both in combination. (C) Survival at 30 days of mice treated with atorvastatin (1.25 mg/kg/day) or risedronate (0.01 mg/kg/day) alone or both in combination. (D) Survival at 30 days of mice treated with atorvastatin (1.25 mg/kg/day) or C7S (0.03 mg/kg/day) alone or both in combination. In all cases, treatment was started 6 h after initial infection and administered daily for 10 days, and 5 mice per group were used. The results for each combination are from two independent experiments. Statistical analysis using the Kaplan-Meier log rank test indicated significant differences (P < 0.0001) between the results for control animals (untreated) and animals treated with the different drug combinations (A to D). Error bars show standard deviations.