TABLE 1.
Biological activities of C7S and other bisphosphonates against T. gondii tachyzoites, TgFPPS, and HsFPPSa
| Compound | Mean T. gondii EC50 ± SD (μM) | Mean IC50 ± SD (μM) for: |
|
|---|---|---|---|
| TgFPPS | HsFPPS | ||
| C7S | 1.49 ± 0.38 | 0.03 ± 0.000 | 1.31 ± 0.53 |
| Risedronate | 2.40 ± 0.7 | 0.44 ± 0.01 | 0.40 ± 0.01 |
| Zoledronate | 0.84 ± 0.04 | 0.07 ± 0.02 | 0.43 ± 0.04 |
| Alendronate | 32.88 | 0.14 ± 0.05 | 5.13 ± 1.77 |
| Atovaquone | 0.032 ± 0.019 | ND | ND |
a
Results are expressed as mean values ± SD from three independent experiments except for growth with alendronate, which has very low in vitro activity. ND, not determined.