TABLE 4.
Combinations of statins and C7S against T. gondii in vitro
| Combination tested | Mean sum FICa | Synergyb |
|---|---|---|
| Cerivastatin + C7S | 0.18 ± 0.09 | ++ |
| Pitavastatin + C7S | 0.25 ± 0.07 | ++ |
| Atorvastatin + C7S | 0.32 ± 0.11 | ++ |
| Lovastatin + C7S | 0.43 ± 0.12 | + |
| Simvastatin + C7S | 0.51 ± 0.26 | +− |
| Mevastatin + C7S | 0.54 ± 0.19 | +− |
| Atorvastatin + atovaquone | 0.55 ± 0.13 | +− |
a
Results are expressed as mean values ± SD from three independent experiments.
b
++, strong synergistic interaction (sum FIC < 40); +, synergy (sum FIC < 50); +−, very mild synergy, not a very strong interaction (sum FIC < 60).