TABLE 2.

Pharmacokinetic, human plasma binding, stool level, and neonatal mouse C. parvum efficacy results

Compound no.	Solubility pH 6.5 (μM)	Cmax (μM)	AUC (μM · min)	Human plasma binding (%)	Neonatal mice (25 mg/kg) (% reduction of infection)a	Fecal concentration (μM)
2	26.0b	9.9b	2,428b	74	39b	0.45
4	83.5b	5.3b	1,694b	89	36	0.05
7	10.9b	NDd	ND	ND	8	0.83
12	83.7b	23.4b	18,450b	84	37	ND
14	96.3b	12.9	9,098	82	56	0.42
16	>100c	2.7	339	86	53	1.06
17	8.7	ND	ND	86	24	ND
Paromomycin		ND	ND	ND	18	ND

^aDetermined by histopathologic scoring of intestinal infection levels at 92 to 94 h postinfection.

^bData were reported previously (8, 12, 13).

^cData at pH 7.4.

^dND, not determined.