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Relationship between the log10 CFU/lung of P. aeruginosa PAO1 at 24 h and the PK/PD indices for AUCELF/MIC (A), Cmax,ELF/MIC (B), fAUCPlasma/MIC (C), and fCmax Plasma/MIC (D). %T>MIC,ELF and %fT>MIC,Plasma could not be adequately examined. The broken line represents the average bacterial burden in the lungs at the start of aerosolized polymyxin B treatment.
