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PK parameters for polymyxin B following pulmonary and intravenous administration in neutropenic infected mice
| Parameter and sample source | Value after single dose |
||
|---|---|---|---|
| Pulmonary |
Intravenousa | ||
| 4.12 mg base/kg | 8.24 mg base/kg | 4.12 mg base/kg | |
| ELF | |||
| Cmax, ELF (mg/liter) | 107 ± 24.6 | 184 ± 35.1 | NA |
| AUCELF (mg · h/liter) | 601 | 1,203 | <LOQ |
| Plasma | |||
| fCmax, Plasma (mg/liter) | 0.46 ± 0.04 | 1.00 ± 0.08 | NA |
| Tmax (min) | 15 | 15 | NA |
| fAUCPlasma (mg · h/liter) | 1.10 | 2.25 | 1.10 |
NA, not applicable.
