TABLE 3.
PK/PD model parameters for AUCELF/MIC and fAUCplasma/MIC of aerosolized polymyxin B against three strains of P. aeruginosa
| Strain and sample source | Value(s) (% RSE) for PK/PD parametera: |
||||
|---|---|---|---|---|---|
| Emax (log10 CFU/lung) | EO (log10 CFU/lung) | EI50 | γ | R2 | |
| ELF | |||||
| ATCC 27853 | 4.74 (11.6) | 8.54 (3.26) | 1340 (4.67) | 9.99 (61.5) | 0.70 |
| PAO1 | 4.65 (10.8) | 8.54 (3.21) | 1,335 (4.60) | 9.94 (59.7) | 0.71 |
| FADDI-PA022 | 4.34 (7.51) | 8.54 (1.48) | 1,528 (4.73) | 9.02 (29.7) | 0.88 |
| Plasma | |||||
| ATCC 27853 | 6.61 (29.6) | 9.06 (4.61) | 3.35 (24.2) | 2.80 (42.5) | 0.70 |
| PAO1 | 5.84 (19.9) | 9.62 (2.71) | 3.50 (15.0) | 3.63 (33.3) | 0.79 |
| FADDI-PA022 | 4.70 (11.0) | 8.63 (1.80) | 3.61 (7.40) | 5.13 (26.2) | 0.87 |
a
E0 is the effect in the absence of polymyxin B treatment; Emax is the maximal effect; EI50 is the value of fAUC/MIC required to achieve 50% of Emax; γ is the Hill coefficient.