TABLE 4.
Polymyxin B AUCELF/MIC and fAUCplasma/MIC target values associated with bacteriostasis and 1- and 2-log10 killsa
| Strain | Target valueb |
||
|---|---|---|---|
| Stasis | 1-log10 kill | 2-log10 kill | |
| AUCELF/MIC | |||
| ATCC 27853 | 1,506 (1,337–1,951) | 1,922 (1,422–2,663) | ND |
| PAO1 | 1,326 (1,213–1,448) | 1,453 (1,315–1,773) | 1,693 (1,410–2,558) |
| FADDI-PA022 | 1,416 (1,296–1,512) | 1,573 (1,470–1,697) | 1,778 (1,635–2,076) |
| fAUCplsma/MIC | |||
| ATCC 27853 | 4.03 (2.44–7.53) | 5.24 (2.89–10.6) | ND |
| PAO1 | 3.78 (2.91–5.30) | 4.68 (3.46–7.57) | 6.70 (4.01–10.9) |
| FADDI-PA022 | 3.14 (2.72–3.51) | 3.73 (3.32–4.26) | 4.49 (3.89–5.74) |
a
Results show target values associated with bacteriostasis and 1- and 2-log10 kills against all three strains of P. aeruginosa in the mouse lung infection model.
b
Values in parentheses are the 10th to 90th percentile ranges generated from Monte Carlo simulation. ND, not determined.