TABLE 5.

Histopathological examination of lung toxicity in healthy and P. aeruginosa-infected mouse lungs 24 h after pulmonary administration of polymyxin B

Amt of polymyxin B (mg base/kg)	Dosing regimen	Histopathological result for:
		Noninfected healthy mice		Neutropenic infected mice
		n	Avg SQS	n	Avg SQS
Saline	Once daily	4	0.00	NA	NA
Saline	Twice daily	3	0.00	NA	NA
Saline	Thrice daily	4	+0.50	NA	NA
Growth control	NAa	NA	NA	8	+2.00
2.06	Once daily	3	+1.00	NA	NA
2.06	Twice daily	3	+1.00	NA	NA
2.06	Thrice daily	3	+0.33	NA	NA
4.12	Once daily	3	+1.00	4	+2.00
4.12	Twice daily	3	+1.33	4	+1.00
4.12	Thrice daily	3	+1.00	4	+0.75
8.24	Once daily	3	+1.00	4	+2.25
8.24	Twice daily	3	+1.00	3	+1.00
8.24	Thrice daily	3	+1.33	5	+1.40
10.3	Once daily	3	+0.67	NA	NA
10.3	Twice daily	3	+1.33	NA	NA

^aNA, not applicable.