TABLE 1.

PK parameters in blood after i.p. administration of 3.74 mg/kg (8.2 μmol/kg) albitiazolium^a

Group and compartment	Cmax (μM)	Tmax (h)	AUC0–inf (μmol · h/liter)	AUC ratiob	t1/2 elim (h)	CL/F (liters/h/kg)	V/F (liters/kg)
Uninfected mice
RBC	0.35	0.25	0.57		7.9
Plasma	8.05	0.083	2.49		4.52	3.3	21.5
Mice with 0.9% parasitemia
RBC + IRBC	0.86	0.083	1.9	3.3	8.01
IRBC	64.24	0.083	190.74	335	8.72
Plasma	8.73	0.083	2.86	1.15	9.05	2.84	37.1
Mice with 8.9% parasitemia
RBC + IRBC	3.48	0.5	11.73	20.6	8.8
IRBC	39.82	0.5	188.54	331	37.7
Plasma	8.22	0.083	4.2	1.69	8.8	1.95	24.7

^aC_max, the highest (maximum) observed concentration; T_max, the time to C_max relative to the time of dosing; AUC_0–inf, total area under the concentration-time curves from time zero to infinity; t_{1/2 elim}, elimination half-life; CL/F, total clearance; V/F, steady-state volume of distribution.

^bThe AUC ratio is the AUC for infected mice/AUC for uninfected mice.