TABLE 2.

PK parameters in tissues^a

Group	AUC0–inf (μmol · h/kg)			t1/2 elim (h)
	Liver	Brain	Heart	Liver	Brain
Uninfected mice	93.5	0.98	220b	9	4.91
Mice with 0.9% parasitemia	82.5	1.32	262b	14.3	10.8
Mice with 8.9% parasitemia	42	2.19	204b	11.5	8

^aAUC_0–inf, total area under the concentration-time curves from time zero to infinity; t_{1/2 elim}, elimination half-life.

^bData represent the AUC from time zero to 35 h.