TABLE 3.

Kinetic parameters after administration of albitiazolium directly in the blood circulation in saline solution or after being accumulated within IRBC^a

Dose injected (mg/kg)b	Compartment	Saline solution			Loaded IRBC
		Cmaxc	Tmax (h)	AUCd	Cmaxc	Tmax (h)	AUCd
0.15	(I)RBC	0.059	0.017	0.51	3.91	0.083	28.21
	Plasma	1.27	0.017	0.64	0.33	0.083	1.92
0.09	(I)RBC	0.018	0.5	blq	1.326	0.25	5.00
	Plasma	0.117	0.083	0.40	0.221	0.083	0.64
0.15	Spleen	0. 2	0.017	13	2.1	1	269
	Liver	ND	ND	ND	ND	ND	ND
0.09	Spleen	0. 04	0.083	1	2.5	2	193
	Liver	2.2	0.5	17	1.5	2	21

^aC_max, the highest (maximum) observed concentration; T_max, the time to C_max relative to the time of dosing; AUC, area under the concentration-time curve; (I)RBC, RBC plus IRBC; ND, not determined; blq, below the limit of quantification.

^bA dose of 0.15 mg/kg corresponds to 0.33 μmol/kg, and a dose of 0.09 mg/kg corresponds to 0.2 μmol/kg.

^cUnits for C_max are micromolar for (I)RBC and plasma and micromoles per kilogram of tissue for spleen and liver.

^dUnits for AUC are micromoles · hour per liter for (I)RBC and plasma and micromoles · hour per kilogram of tissue for spleen and liver.