TABLE 4.
Comparison of previously published micafungin pharmacokinetic parameters
| Parametera | Value for drug from indicated referenceb |
||||||
|---|---|---|---|---|---|---|---|
| Anidulafungin (24) | Anidulafungin (25) | Anidulafungin (26) | Caspofungin (23)c | Micafungin (27) | Micafungin (28) | Micafungin (14) | |
| VD (liters) | 41.97 ± 22.64 | 138 (121 ml/kg) | 17.5 ± 4.4 | ||||
| t1/2β (h) | 28.78 ± 10.40 | 11.7 (8.1) | |||||
| Cmax, 0–24 (mg/liter) | 7.36 | 6.2 ± 1.7 | 8.5 ± 3.6 | 8.4 (17.2) | 6.31 ± 1.08 | 12.7 ± 10.2 | 9.15 ± 1.95 |
| Ctrough (mg/liter) | 2.02 | 3.0 ± 0.6 | 2.9 ± 1.1 | 2.46 ± 0.75 | |||
| CLtot (liters/h) | 1.08 ± 0.41 | 7.8 (3.7 ml/h/kg) | 0.054 ± 0.04 ml/min/kg | 1.4 ± 0.7 | 0.88 ± 0.27 | ||
| AUC0–24 (mg · h/liter) | 81.33 | 93.9 ± 9.4 | 109.9 ± 49.82 | 91 (127) | 50.04 ± 6.48d | 119.01 ± 27.20 | |
| Dosage (mg) | 200 mg LD, 100 mg MD | 200 mg LD, 100 mg MD | 200 mg LD, 100 mg MD | 70 mg | 40–50 mg | 150–300 mg | 100 mg |
a
AUC, area under curve; CLtot, total body clearance; Cmax, 0–24, maximum micafungin concentration during the first 24 h; Ctrough, micafungin trough concentration; VD, volume of distribution; t1/2β, terminal half-life time.
b
Unless otherwise indicated, units of measurement are as described for the parameters. LD, loading dose; MD, maintenance dose.
c
Ranges for this drug are given in parentheses.
d
This value is the AUC0–12.