TABLE 1.
In vitro activities of antimicrobial agents against K. pneumoniae isolates and their transformants
| Strain | β-Lactamase(s) | MIC (mg/liter)a |
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ETP | IPM | MEM | CSL | CZO | CXM | CTX | CAZ | CMZ | TGC | FEP | PIP | TZP | CIP | LEV | GEN | AMK | CST | ATM | CHL | MNO | SXT | ||
| KP1 | OXA-232, SHV-1/CTX-M-15 | 32 | 1 | 4 | 128/64 | >32 | >64 | >32 | >32 | 32 | 1 | >32 | >256 | >256/4 | >8 | >16 | >32 | >128 | ≤1 | >64 | >32 | 16 | >8/152 |
| KP1-T | OXA-232 | 0.25 | 0.5 | 0.06 | 8/4 | 8 | 16 | ≤0.25 | ≤0.25 | 32 | ≤0.25 | ≤0.5 | 256 | 64/4 | ≤0.25 | ≤0.5 | ≤2 | ≤8 | ≤1 | ≤2 | ≤8 | ≤2 | ≤1 |
| KP2 | OXA-232, SHV-1/CTX-M-15 | 32 | 2 | 8 | 128/64 | >32 | >64 | >32 | >32 | 16 | 1 | >32 | >256 | >256/4 | >8 | >16 | >32 | >128 | ≤1 | >64 | >32 | 16 | >8/152 |
| KP2-T | OXA-232 | 0.5 | 0.5 | 0.06 | 16/8 | 8 | 8 | ≤0.25 | ≤0.25 | 8 | ≤0.25 | ≤0.5 | 128 | 32/4 | ≤0.25 | ≤0.5 | ≤2 | ≤8 | ≤1 | ≤2 | ≤8 | ≤2 | ≤1 |
| KP3 | OXA-232, SHV-1/CTX-M-15 | 64 | 1 | 4 | >128/64 | >32 | >64 | >32 | >32 | 32 | 2 | >32 | >256 | >256/4 | >8 | >16 | >32 | >128 | ≤1 | >64 | >32 | 16 | >8/152 |
| KP3-T | OXA-232 | 0.25 | 0.5 | 0.06 | 16/8 | 8 | 8 | ≤0.25 | ≤0.25 | ≤0.5 | ≤0.25 | ≤0.5 | 256 | 64/4 | ≤0.25 | ≤0.5 | ≤2 | ≤8 | ≤1 | ≤2 | ≤8 | ≤2 | ≤1 |
| KP4 | OXA-232, SHV-1/CTX-M-15 | 32 | 1 | 4 | >128/64 | >32 | >64 | >32 | >32 | ≤0.5 | 1 | >32 | >256 | >256/4 | >8 | >16 | >32 | >128 | ≤1 | >64 | >32 | 16 | >8/152 |
| KP4-T | OXA-232 | 0.25 | 0.5 | ≤0.03 | 16/8 | 8 | 8 | ≤0.25 | ≤0.25 | ≤0.5 | ≤0.25 | ≤0.5 | >256 | 64/4 | ≤0.25 | ≤0.5 | ≤2 | ≤8 | ≤1 | ≤2 | ≤8 | ≤2 | ≤1 |
| KP5 | OXA-232, SHV-1/CTX-M-15 | 64 | 2 | 4 | 128/64 | >32 | >64 | >32 | >32 | ≤0.5 | 1 | >32 | >256 | >256/4 | >8 | >16 | >32 | >128 | ≤1 | >64 | >32 | 16 | >8/152 |
| KP5-T | OXA-232 | 0.25 | 0.5 | 0.06 | 16/8 | 8 | 8 | ≤0.25 | ≤0.25 | 1 | ≤0.25 | ≤0.5 | 128 | 64/4 | ≤0.25 | ≤0.5 | ≤2 | ≤8 | ≤1 | ≤2 | ≤8 | ≤2 | ≤1 |
| E. coli DH5α | ≤0.03 | 0.125 | ≤0.03 | ||||||||||||||||||||
a
ETP, ertapenem; IPM, imipenem; MEM, meropenem; CSL, cefoperazone-sulbactam; CZO, cefazolin; CXM, cefuroxime; CTX, cefotaxime; CAZ, ceftazidime; CMZ, cefmetazole; TGC, tigecycline; FEP, cefepime; PIP, piperacillin; TZP, piperacillin-tazobactam; CIP, ciprofloxacin; LEV, levofloxacin; GEN, gentamicin; AMK, amikacin; CST, colistin; ATM, aztreonam; CHL, chloramphenicol; MNO, minocycline; SXT, trimethoprim-sulfamethoxazole.