TABLE 1.
Breakpoint table for interpretation of EUCAST and CLSI MICs of echinocandins and Sensititre ECOFFs
| Antifungal agent | Species | MIC breakpoint (mg/liter) |
Sensititre ECOFF (μg/ml) | ||||
|---|---|---|---|---|---|---|---|
| EUCAST |
CLSI |
||||||
| S | R | S | I | R | |||
| Anidulafungin | C. albicans | ≤0.03 | >0.03 | ≤0.25 | 0.5 | ≥1 | 0.12 |
| C. glabrata | ≤0.06 | >0.06 | ≤0.12 | 0.25 | ≥0.5 | 0.12 | |
| C. krusei | ≤0.06 | >0.06 | ≤0.25 | 0.5 | ≥1 | 0.25 | |
| C. parapsilosis | ≤0.002 | >4 | ≤2 | 4 | ≥8 | 4 | |
| C. tropicalis | ≤0.06 | >0.06 | ≤0.25 | 0.5 | ≥1 | 0.5 | |
| Caspofungin | C. albicans | IEa | ≤0.25 | 0.5 | ≥1 | 0.25 | |
| C glabrata | IE | ≤0.12 | 0.25 | ≥0.5 | 0.25 | ||
| C. krusei | IE | ≤0.25 | 0.5 | ≥1 | 1 | ||
| C. parapsilosis | IE | ≤2 | 4 | ≥8 | 2 | ||
| C. tropicalis | IE | ≤0.25 | 0.5 | ≥1 | 0.25 | ||
| Micafungin | C. albicans | ≤0.016 | >0.016 | ≤0.25 | 0.5 | ≥1 | 0.06 |
| C. glabrata | ≤0.03 | >0.03 | ≤0.06 | 0.12 | ≥0.25 | 0.03 | |
| C. krusei | IE | ≤0.25 | 0.5 | ≥1 | 0.25 | ||
| C. parapsilosis | ≤0.002 | >2 | ≤2 | 4 | ≥8 | 4 | |
| C. tropicalis | IE | ≤0.25 | 0.5 | ≥1 | 0.06 | ||
a
IE, insufficient evidence.