TABLE 2.

In vitro susceptibilities of Candida species to anidulafungin, caspofungin, and micafungin as determined by EUCAST, Etest, and Sensititre after 24 h, including EA and CA

Drug and species	No. of isolates	EUCAST MIC			Etest MICa			Sensititre MIC			EA (%)		CA with EUCAST (%)		CA with CLSI (%)		CA by use of Sensititre ECOFF (%)
		Range	50%	90%	Range	50%	90%	Range	50%	90%	Etest	Sensititre	Etest	Sensititre	Etest	Sensititre
Anidulafungin
Total	104	0.002–0.5	0.009	0.016	0.002–1.5	0.003	0.016	0.015–1	0.015	0.108	97	92	99	93	99	100	100
C. albicans	63	0.002–0.016	0.002	0.016	0.002–0.006	0.003	0.004	0.015–0.06	0.015	0.030	100	100	100	97	100	100	100
C. dubliniensis	2	0.002–0.002	0.002	0.002	0.002–0.006	0.004	0.006	0.015–0.12	0.068	0.110	100	50	100	50	100	100
C. glabrata	18	0.002–0.031	0.016	0.016	0.002–0.25	0.007	0.008	0.015–0.12	0.015	0.030	94	100	94	94	94	100	100
C. kefyr	1	0.016	0.016	0.016	0.016	0.016	0.016	0.015	0.015	0.015	100	100	NAb	NA	NA	NA
C. krusei	5	0.016–0.031	0.016	0.025	0.012–0.023	0.016	0.020	0.03–0.06	0.030	0.048	100	100	100	100	100	100	100
C. lusitaniae	1	0.016	0.016	0.016	0.032	0.032	0.032	0.12	0.120	0.120	100	0	NA	NA	NA	NA
C. orthopsilosis	1	0.031	0.031	0.031	0.38	0.380	0.380	0.25	0.250	0.250	0	0	100	100	100	100	100
C. parapsilosis	4	0.125–0.5	0.375	0.500	0.38–1.5	1.000	1.350	0.5–1	0.750	1.000	75	75	100	100	100	100	100
C. pararugosa	1	0.002	0.002	0.002	0.032*	0.032*	0.032*	0.06*	0.06*	0.06*	100	0	NA	NA	NA	NA
C. tropicalis	8	0.002–0.016	0.016	0.016	0.003—0.008	0.006	0.007	0.015–0.12	0.060	0.120	100	63	100	63	100	100	100
Caspofungin
Total	104	0.002–0.25	0.031	0.063	0.023–0.5	0.094	0.354	0.015–0.5	0.060	0.120	74	98	NA	NA	92	99	100
C. albicans	63	0.002–0.062	0.031	0.062	0.023–0.125	0.064	0.094	0.015–0.06	0.060	0.060	71	100	NA	NA	100	100	100
C. dubliniensis	2	0.031–0.031	0.031	0.031	0.047–0.094	0.071	0.089	0.03–0.12	0.075	0.111	100	100	NA	NA	100	100
C. glabrata	18	0.016–0.125	0.062	0.063	0.064–0.38	0.125	0.190	0.03–0.25	0.060	0.120	89	100	NA	NA	83	94	100
C. kefyr	1	0.031	0.031	0.031	0.023	0.023	0.023	NA	0.015	0.015	100	100	NA	NA	NA	NA
C. krusei	5	0.063–0.125	0.125	0.125	0.38–0.5	0.380	0.452	0.12–0.25	0.250	0.250	60	100	NA	NA	0	100	100
C. lusitaniae	1	0.063	0.063	0.063	0.25	0.250	0.250	NA	0.060	0.060	100	100	NA	NA	NA	NA
C. orthopsilosis	1	0.031	0.031	0.031	0.38	0.380	0.380	NA	0.250	0.250	0	0	NA	NA	100	100	100
C. parapsilosis	4	0.062–0.25	0.125	0.213	0.38–0.38	0.380	0.380	0.12–0.5	0.250	0.425	75	100	NA	NA	100	100	100
C. pararugosa	1	0.002	0.002	0.002	0.19*	0.19*	0.19*	0.12*	0.12*	0.12*	0	0	NA	NA	NA	NA
C. tropicalis	8	0.016–0.063	0.031	0.063	0.032–0.094	0.079	0.094	0.03–0.06	0.060	0.060	75	100	NA	NA	100	100	100
Micafungin
Total	104	0.002–0.25	0.002	0.016	0.003–0.5	0.006	0.064	0.008–1	0.015	0.060	92	92	99	97	99	100	99
C. albicans	63	0.002–0.016	0.002	0.016	0.003–0.012	0.006	0.008	0.008–0.03	0.008	0.015	100	100	100	98	100	100	100
C. dubliniensis	2	0.002–0.002	0.002	0.002	0.004–0.008	0.006	0.008	0.015–0.06	0.038	0.056	100	100	100	50	100	100
C. glabrata	18	0.002–0.016	0.002	0.016	0.004–0.064	0.006	0.008	0.008–0.06	0.015	0.015	94	100	94	94	94	100	94
C. kefyr	1	0.016	0.016	0.016	0.032	0.032	0.032	0.03	0.030	0.030	100	100	NA	NA	NA	NA
C. krusei	5	0.016–0.062	0.016	0.043	0.064–0.094	0.064	0.094	0.12–0.12	0.120	0.120	20	20	NA	NA	100	100	100
C. lusitaniae	1	0.016	0.016	0.016	0.032	0.032	0.032	0.03	0.030	0.030	100	100	NA	NA	NA	NA
C. orthopsilosis	1	0.016	0.016	0.016	0.19	0.190	0.190	0.5	0.500	0.500	0	0	100	100	100	100	100
C. parapsilosis	4	0.062–0.25	0.188	0.250	0.25–0.5	0.315	0.464	0.25–1	0.750	1.000	75	50	100	100	100	100	100
C. pararugosa	1	0.002	0.002	0.002	0.032*	0.032*	0.032*	0.12*	0.12*	0.12*	100	0	NA	NA	NA	NA
C. tropicalis	8	0.002–0.016	0.016	0.016	0.008–0.12	0.012	0.047	0.015–0.03	0.030	0.030	88	100	NA	NA	100	100	100

^a*, read after 48 h.

^bNA, not applicable, since no breakpoints were defined.