TABLE 2.

Synergy of P128 and SoC antibiotics on planktonic cells of CoNS strains assayed by checkerboard microdilution method^a

CoNS strain	Vancomycin					Daptomycin					Linezolid
	P128 MIC	Van MIC	P128 + Van		FICI	P128 MIC	Dap MIC	P128 + Dap		FICI	P128 MIC	Lin MIC	P128 + Lin		FICI
			P128 MIC	Van MIC				P128 MIC	Dap MIC				P128 MIC	Lin MIC
S. epidermidis B9468	1.66 ± 0.57	1.66 ± 0.57	0.83 ± 0.28	0.33 ± 0.14	0.7	2	0.83 ± 0.28	0.16 ± 0.07	0.25	0.38	2	2	0.41 ± 0.14	0.5	0.45
S. epidermidis B9470	2	2	1.41 ± 1.01	0.5 ± 0.43	0.95	2	1	0.20 ± 0.07	0.5	0.60	2.66 ± 1.15	2	0.41 ± 0.14	0.5	0.40
S. epidermidis B9471	21.33 ± 9.23	2.66 ± 1.15	1.41 ± 1.01	2.66 ± 1.15	1.06	32	2	1.33 ± 0.57	0.5	0.29	26 ± 9.23	1	6.66 ± 2.30	0.25	0.50
S. haemolyticus B9478	64	4	4	2	0.56	64	1	0.25	0.33 ± 0.14	0.33	64	1	3.33 ± 1.15	0.33 ± 0.14	0.38
S. haemolyticus B9511	6.66 ± 2.30	1.33 ± 0.57	1.66 ± 0.57	0.18 ± 0.27	0.29	2.66 ± 1.15	0.83 ± 0.28	1.33 ± 0.57	0.18 ± 0.10	0.72	6.66 ± 2.30	1	0.83 ± 0.28	0.25	0.37
S. lugdunensis B9476	8	1	0.5 ± 0.43	0.41 ± 0.14	0.47	16	1.33 ± 0.57	0.75 ± 0.43	0.33 ± 0.14	0.29	16	1	1.66 ± 0.57	0.25	0.35
S. lugdunensis B9510	10.66 ± 4.61	2	0.41 ± 0.14	0.5	0.28	16	0.5	0.33 ± 0.14	0.08 ± 0.03	0.18	13.33 ± 4.61	1	2	0.25	0.40

^aMIC values (in micrograms per milliliter) are the average ± standard deviation (SD) of three values; where triplicate values were identical, no SD values are shown.