TABLE 3.

Synergy of P128 and SoC antibiotics on 72-h preformed biofilms of CoNS strains assayed by checkerboard microdilution method^a

CoNS strain	Vancomycin					Daptomycin					Linezolid
	P128 MBIC	Van MBIC	P128 + Van		FICI	P128 MBIC	Dap MBIC	P128 + Dap		FICI	P128 MBIC	Lin MBIC	P128 + Lin		FICI
			P128 MBIC	Van MBIC				P128 MBIC	Dap MBIC				P128 MBIC	Lin MBIC
S. epidermidis B9470	26.66 ± 9.23	7.8	1.79 ± 1.84	2.56 ± 1.15	0.39	13.33 ± 4.61	20.8 ± 9.0	1	3.9	0.26	13.33 ± 4.61	7.8	1	0.45	0.13
S. epidermidis B9471	26.66 ± 9.23	208.33 ± 72.16	0.76 ± 0.23	13 ± 4.50	0.09	26.66 ± 9.23	13.0 ± 4.5	1.33 ± 0.57	2.09 ± 1.71	0.21	10.66 ± 4.61	250	1.33 ± 0.57	1.23 ± 0.57	0.12
S. epidermidis B9472	26.66 ± 9.23	250	6.53 ± 2.19	46.86 ± 27.07	0.43	32	7.8	1	0.68 ± 0.38	0.11	26.66 ± 9.23	250	1	0.76 ± 0.24	0.04
S. haemolyticus B9511	8.19 ± 3.22	250	1.28 ± 0.88	16.9 ± 13.69	0.21	13.66 ± 2.02	250	1.37 ± 0.32	26.0 ± 9.0	0.20	6.83 ± 1.01	250	1.70 ± 0.25	0.25 ± 0.55	0.37
S. lugdunensis B9510	32	250	0.83 ± 0.28	7.8	0.05	21.33 ± 9.23	15.6	2.66 ± 1.15	2.09 ± 1.70	0.25	21.33 ± 9.23	208.33 ± 72.16	1.66 ± 0.57	6.06 ± 8.54	0.10

^aMBIC values (in micrograms per milliliter) are the average ± standard deviation (SD); where triplicate values were identical, no SD values are shown. Van, vancomycin; Dap, daptomycin; Lin, linezolid.