TABLE 1.

Patient's laboratory values after different doses of posaconazole^a

Test name	Posaconazole, 300 mg daily	21 days after posaconazole cessation	Posaconazole, 100 mg daily	Normal range
ACTH (pg/ml)	47			6–50
Pregnenolone (ng/dl)	89			13–208
17-Hydroxypregnenolone (ng/dl)	147			≤905
Progesterone (ng/ml)	<0.5			<1.4
17-Hydroxyprogesterone (ng/dl)	129			37–129
Aldosterone (ng/dl)	<1 ng/dl	4	3	3–16
Renin activity (ng/ml/h)	0.11	1.34	2.47	0.25–5.82
DHEA (ng/dl)	175			61–1636
11-Deoxycortisol (ng/dl)	177	36	<20	≤42
Deoxycorticosterone (ng/dl)	2			≤15
Corticosterone (ng/dl)	885			59–1,293
Cortisol (μg/dl)	14.6			4–22
Cortisone (μg/dl)	1.4			1.2–3.5
Testosterone (ng/dl)	911			250–1,100
Free testosterone (pg/ml)	36.9			35–155
Estrone (pg/ml)	55	23		≤68
Estradiol (pg/ml)	48	35	26	≤39
Estriol (ng/ml)	<0.10	<0.10	<0.10	<0.18
Serum potassium (mmol/L)	3.4	4.9	4.4	3.5–5.3
Serum osmolality (mOsm/kg)	287		284	278–305
Urine potassium (mmol/L)	29		47	12–129
Urine osmolality (mOsm/kg)	358		557	50–1,200
Serum posaconazole (μg/ml)	4.36	NAb	1.24	>0.70

^aAll blood samples for laboratory testing were drawn at 8 a.m.

^bNA, not applicable.