FIG 4.

Survival curves of menoctone-sensitive (A, C) versus menoctone-resistant (B, D) P. berghei following treatment with menoctone or atovaquone. Menoctone offers some protection to P. berghei luc ANKA-infected mice (A) but demonstrates a marked decrease in protection against menoctone-resistant parasite P. berghei MEN-R (B). Atovaquone provided significantly more efficacy than menoctone (C); however, even at the highest dose of 10 mg/kg, atovaquone was not effective at preventing recrudescence of P. berghei MEN-R (D).