FIG 3.

Susceptibility of HIV-1 and HIV-2 isolates from ART-naive individuals to MK-8591. (A) EC₅₀s for 10 HIV-1 and 14 HIV-2 strains. Bars are the means of results from three or more independent single-cycle assays. Error bars are +1 standard deviation. Group/subtype assignments are shown in parentheses. The HIV-2 intergroup recombinant 7312A encodes a group B pol gene (57). (B) Summary for the isolates shown in panel A. Each point represents the mean EC₅₀ for a single isolate. (C) Comparison of EC₅₀s for group A and B isolates of HIV-2. In panels B and C, the horizontal lines are the means from the respective data groups; P values are the results of Welch's t tests.