TABLE 2.
Activity profile of MNP-derived pure compoundsa
| Compound | Formula | Molecular mass (kDa) | MICR (μg/ml)a | MICD (μg/ml)b | MICR/MICD | IC50 (μg/ml) | SIRc | SIDd | Source |
|---|---|---|---|---|---|---|---|---|---|
| 1 | C31H30Br6N4O11 | 1,114.02 | 8.5 | Inactive | NA | >200 | >23.5 | NA | HBOI.047.F07 |
| 2 | C19H40O3 | 316.53 | 60.8 | 22.5 | 2.7 | >200 | >3.3 | >8.5 | HBOI.047.F07 |
| 3 | C16H30O2 | 254.41 | 28.5 | 7.9 | 3.6 | >200 | >7.0 | >31.1 | HBOI.031.C02 |
| 4 | C22H32O4 | 360.49 | 11.3 | 0.5 | 21.8 | 8 | 0.7 | 15.5 | HBOI.050.F04 |
| 5 | C21H26O3 | 326.44 | 87.6 | 15.4 | 5.6 | 50.4 | 0.6 | 6.2 | HBOI.050.F04 |
a
MICR, MIC against replicating Mtb-Lux.
b
MICD, MIC against dormant Mtb-Lux.
c
SIR, SI for replicating Mtb-Lux.
d
SID, SI for dormant Mtb-Lux.