FIG 8.

Selection of resistance to 6940_B01. NL4-3 virus was passaged in the presence of increasing concentrations of 6940_B01 (dashed line). Breakthrough virus from every third passage was analyzed for decreased susceptibility to 6940_B01 (solid line), and the gp160 gene was population sequenced to identify selected changes. Percentages represent the estimated percentage of genes within the population that contained the substitution. If there is no number next to a sequence, the prevalence of this mutation is believed to be 100%.