TABLE 5.
Amino acid substitutions after prolonged selection in the presence of 6940_B01
| Virus | Passage no. | No. of days in culture | Fold reduced susceptibility | Amino acid at the following positiona: |
|||
|---|---|---|---|---|---|---|---|
| S143 | N197 | N301 | S465 | ||||
| Control (no drug) | 30 | 151 | 1 | S | N | N | S |
| Selected virus population | 30 | 151 | 11.5 | Rb | Db | Kb | Pb |
| Recombinant virus | 7 | R | D | K | P | ||
a
The amino acid sequence and the position numbering are based upon the HXB2 sequence starting with gp120.
b
Results in the loss of a potential N-linked glycosylation site.