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. Author manuscript; available in PMC: 2017 Nov 23.
Published in final edited form as: Trends Cancer. 2016 Nov 23;2(11):646–656. doi: 10.1016/j.trecan.2016.10.014

Figure 4. Endogenous and Exogenous Modulators of Clinical Synthetic Lethality.

Figure 4

A circos plot cartoon is used to describe the relationship between endogenous and exogenous inducers or modulators of DNA damage. This DNA damage may collaborate with DNA repair inhibition to create a clinical synthetic lethal event. Endogenous effectors include genomic instability, somatic/germline mutations, cell cycle defects and oncogenic drivers; whereas, exogenous effectors include the events within the cancer cell microenvironment, immune- or tumor/vascular/stromal-mediated DNA injury, and exogenous processes such as ambient or therapeutic radiation and chemotherapeutics.

Abbreviations: TOP1/2i, topoisomerase 1/2 inhibitor; i, inhibitor