Table 3.

Predictive Performance of Coagulation Tests and Scores for Massive Transfusion

Predictor of massive transfusion	Area under curve (95% CI)	Youden index	Sensitivity, %	Specificity, %	Positive predictive value, %	Negative predictive value, %
Lt-LY30	0.86 (0.79–0.93)	27%	84	82	50	96
Lt-TMA	0.79 (0.71–0.87)	23 min	67	85	45	92
Ht-LY30	0.84 (0.77–0.91)	71%	80	84	50	95
Ht-TMA	0.78 (0.71 – 8.5)	16 min	84	70	36	94
R-MA	0.79 (0.73–0.85)	57mm	68	79	41	92
INR	0.86 (0.81–0.91)	1.1	90	69	33	97
Peltan (11)*		1.5	42	95	58	88
TASH	0.84 (0.79–0.90)	8	87	76	38	97
Brockamp (5)*		8.5	86	74	44	96
Shock index	0.70 (0.61–0.80)	1.07	63	77	37	92
Pottecher (39)*		0.96	68	67	31	92
ABC	0.66 (0.58–0.74)	1	85	37	22	92
Nunez (20)*		2	38	82	30	87

^*Represent threshold recommend by prior researchers as thresholds for massive transfusion.

ABC, assessment of blood consumption score; Ht, high dose tissue plasminogen activator thrombelastography; INR, internal normalized ratio; Lt, low dose tissue plasminogen activator thrombelastography; LY30, percent clot lysis 30 minutes after reaching maximum amplitude; MA, maximum amplitude; R, rapid thrombelastography; TASH, trauma associated severe hemorrhage; TMA, time to maximum amplitude.