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. 2017 Jul 26;8:494. doi: 10.3389/fphar.2017.00494

Figure 6.

Figure 6

The effect of alkaloid-rich (ALK) at 150 mg/kg, non-alkaloid (NON-ALK) at 150 mg/kg extracts, and GABAA receptor modulators in the elevated plus maze. The ALK (150 mg/kg i.p.) extract and diazepam 1 mg/kg i.p. (DZ) increased the % time spent in the open arms of the maze. The ALK (150 mg/kg i.p.) extract plus flumazenil 0,3 mg/Kg s.c. (ALK + FLU) reverted the increase in time spent in the open arms produced by the ALK extract. Similarly, DZ + FLU reverted the increase in time spent in the open arms produced by DZ. Data are shown as mean ± SEM, n = 10/group. *Different from control group (p ≤ 0.05). + Different from ALK group (p ≤ 0.05). #Different from DZ group (p ≤ 0.05). Control: Saline + Tween 20. DZ bar: Diazepam + control, DZ+FLU bar: Diazepam + flumazenil + control.