Table 2.

Results of the meta-analysis of GWAS of asthma in Puerto Ricans, for SNPs associated with asthma in two previous meta-analysis in Europeans (by the GABRIEL consortium) and ethnically diverse North Americans (by the EVE consortium)

SNP	Chr	Position	Ref	Alt	Gene	In cited paper	Hartford-PR			GALA I			GALA II			HCHS/SOL			Combined
						OR	AAF	OR	P-value	AAF	OR	P-value	AAF	OR	P-value	AAF	OR	P-value	OR	P-value
Loci reported by the GABRIEL consortium in Moffatt M.F. et al. N Engl J Med 2010; 363:1211–21
rs3771166	2	102986222	G	A	IL18R1	0.85*	0.45	0.90	0.500	0.44	0.75	0.114	0.43	0.85	0.018	0.46	1.14	0.110	0.94	0.111
rs9273349	6	32625869	A	G	HLA-DQ	1.14	0.61	0.98	0.860	NA	NA	NA	NA	NA	NA	0.62	1.22	0.016	1.13	0.079
rs1342326	9	6190076	A	C	IL33	1.27	0.21	0.90	0.403	0.26	1.12	0.571	0.22	1.05	0.528	0.20	1.13	0.213	1.05	0.376
rs744910	15	67446785	G	A	SMAD3	0.89	0.43	0.88	0.175	0.42	1.01	0.981	0.45	0.93	0.269	0.45	1.05	0.572	0.95	0.326
rs2305480	17	38062196	G	A	GSDMB	0.76	0.31	0.62	2.0×10−6	0.31	0.54	0.003	0.32	0.71	6.7×10−6	0.34	0.86	0.071	0.72	7.4×10−12
rs3894194	17	38121993	G	A	GSDMA	1.26	0.37	1.23	0.034	0.39	0.92	0.648	0.40	1.23	0.002	0.39	0.94	0.406	1.11	0.023
rs2284033	22	37534034	G	A	IL2RB	0.92	0.41	0.91	0.272	0.39	1.09	0.638	0.40	1.17	0.024	0.42	1.00	0.997	1.04	0.289
rs2073643	5	131723288	T	C	SLC22A5	0.89	0.50	0.96	0.668	0.48	1.18	0.356	0.50	0.93	0.257	0.51	1.01	0.856	0.98	0.551
rs1295686	5	131995843	T	C	IL13	0.85	0.59	1.01	0.943	0.62	0.75	0.136	0.62	0.90	0.159	0.61	1.07	0.398	0.96	0.408
rs11071559	15	61069988	C	T	RORA	0.88	0.26	1.07	0.525	0.25	1.69	0.012	0.24	0.90	0.193	0.24	0.85	0.087	0.96	0.486
Replicated genes reported by the EVE consortium in Torgerson D.G. et al. Nat. Genet. 2011; 43(9):887–92
rs1102000	1	158932907	T	C	PYHIN1	0.76#	0.08	1.09	0.651	0.06	0.50	0.061	NA	NA	NA	0.07	1.21	0.986	0.93	0.611
rs10173081	2	102957348	C	T	IL1RL1	0.83	0.19	0.84	0.132	0.16	0.85	0.519	0.26	0.78	0.010	0.18	0.93	0.506	0.84	0.004
rs1837253	5	110401872	C	T	TSLP	0.84	0.25	0.73	0.004	0.23	0.65	0.041	0.27	0.83	0.014	0.26	0.96	0.701	0.82	2.5×10−4
rs2381416	9	6193455	A	C	IL33	1.18	0.38	0.98	0.847	0.39	1.00	0.980	0.37	1.09	0.249	0.35	1.13	0.157	1.07	0.155
rs11078927	17	38064405	C	T	GSDMB	0.79	0.30	0.61	1.4×10−6	0.31	0.55	0.003	0.31	0.71	7.9×10−6	0.34	0.86	0.079	0.72	8.1×10−12

Ref: reference allele; Alt: alternative allele; AAF: alternative allele frequency; OR: odds ratio.

^*This column is childhood onset odds ratio in Moffatt M.F. et al. N Engl J Med 2010; 363:1211–21;

^#This column is overall odds ratio in Torgerson D.G. et al. Nat. Genet. 2011; 43(9):887–92.

Human Genome version: hg19