Loss of H2Bub1 and its association with cellular differentiation and survival of lung adenocarcinoma patients. Photomicrographs of H2Bub1 (upper panel) and total H2B (lower panel) in (a) normal lung tissue, and four representative lung adenocarcinoma tissues scored as (b) 0, (c) 1+, (d) 2+, (e) 3+ (Magnification × 100). (f). Kaplan–Meier analysis for overall survival of patients with H2Bub1 protein (Positive, n=91) or without H2Bub1 protein (Negative, n=79) (Neg v.s Pos, P = 0.237). (g). Kaplan–Meier analysis for recurrence free survival of lung adenocarcinoma patients with H2Bub1 protein (Positive, n=81) or without H2Bub1 protein (Negative, n=72) (Neg V.S Pos, P=0.103).