Table 2.

Univariate Cox Regression Analysis of Disease-free Survival and Overall Survival

Characteristic	No. of patients	Disease-free survival		Overall survival
		HR (95% CI)	p value	HR (95% CI)	p value
Age	389	0.98 (0.97–0.997)	0.01	0.99 (0.98–1.01)	0.21
Sex
Female (reference)	170
Male	219	0.94 (0.84–1.06)	0.33	0.92 (0.81–1.03)	0.15
Tumor differentiation
Well-moderate (reference)	243
Poor	146	1.29 (1.01–1.64)	0.04	1.36 (1.07–1.73)	0.01
Margin status
Negative (reference)	358
Positive	31	1.47 (0.97–2.22)	0.07	1.71 (1.13–2.59)	0.01
Treatment responseCAP score
1 (reference)	54
2 and 3	335	1.69 (1.15–2.47)	0.007	1.78 (1.22–2.61)	0.003
ypT stage by AJCC 8th edition*			0.01		0.006
ypT1 (reference)	152
ypT2	203	1.37 (1.06–1.77)	0.02	1.40 (1.08–1.82)	0.01
ypT3	34	1.71 (1.12–2.62)	0.01	1.83 (1.19–2.80)	0.006
ypT1b vs ypT1a		0.73 (0.25–2.12)	0.56	0.44 (0.13–1.48)	0.18
ypT1c vs ypT1a or ypT1b		1.71 (0.97–3.02)	0.07	1.99 (1.08–3.67)	0.03
ypT2 vs ypT1c		1.21 (0.92–1.59)	0.17	1.15 (0.87–1.52)	0.34
ypT3 vs ypT2		1.36 (0.88–1.98)	0.18	1.36 (0.90–205)	0.15
ypT stage by AJCC 7th edition*			0.01		0.01
ypT1 (reference)	23
ypT2	8	3.06 (1.09–8.59)	0.03	2.71 (0.97–7.63)	0.06
ypT3	358	2.74 (1.41–5.32)	0.003	2.80 (1.44–5.44)	0.002
ypN stage by AJCC 8th edition			0.00		0.00
Negative (ypN0, reference)	175
1–3 positive nodes (ypN1)	141	1.60 (1.22–2.09)	0.001	1.54 (1.17–2.03)	0.002
≥ 4 positive nodes (ypN2)	73	2.65 (1.94–3.62)	0.00	2.67 (1.95–3.66)	0.00

^*Nine patients with ypT0 stage were not included in the analyses as the number of patients in this category was too small.

Abbreviations: HR, Hazard ratio; CI, confidence interval; AJCC, American Joint Committee for Cancer