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. 2008 Mar 7;2(1):70–80. doi: 10.1016/j.molonc.2008.02.004

Figure 4.

Figure 4

STIMA‐1 induces cell death by apoptosis. (A) FACS analysis of Saos‐2‐His273 cells before (upper panel) and after (lower panel) treatment with 15μM STIMA‐1. Doxycycline treatment shuts off expression of mutant p53 in Saos‐2‐His273 cells. (B) Quantification of the sub‐G1 cell fraction after STIMA‐1 treatment. (C) Quantification of caspase activation assays in H1299‐His175 and H1299 cells (left panel), in Saos‐2‐His273 and Saos‐2 cells (middle panel) and in Saos‐2‐His273 and Saos‐2‐His273 (+dox) cells (right panel). Data represent mean±standard error (n=2 or 3).