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. 2008 Mar 27;2(1):41–53. doi: 10.1016/j.molonc.2008.03.006

Figure 3.

Figure 3

Schematic representation of the HIF‐1 pathway. Under normoxic conditions HIF‐1α is hydroxylated and rapidly degraded (A). Under hypoxic conditions the HIF‐1 complex is stabilised and initiates the transcription of its target genes. EGFR can activate HIF‐1α in an oxygen‐independent way (B).