Table 3.
Pearson correlation analysis of 23 different MMPs with the four TIMPs
| Gene | Probe set | Median log2 | p‐value | log2 ratio | Pearson correlation coefficient | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal | Tumour | TIMP‐1 | TIMP‐2 | TIMP‐3 | TIMP‐4 | ||||||
| 201666_at | 231579_s_at | 201150_s_at | 206243_at | ||||||||
| MMP1 | 204475_at | 5.16 | 10.43 | 8.36E‐09 | 5.26 | ↑ | * | 0.52 | 0.40 | 0.38 | 0.00 |
| MMP2 | 201069_at | 7.96 | 8.62 | 1.97E‐03 | 0.66 | ↑ | * | 0.67 | 0.88 | 0.70 | 0.05 |
| MMP3 | 205828_at | 3.38 | 9.08 | 1.05E‐32 | 5.71 | ↑ | 0.44 | 0.28 | 0.29 | −0.05 | |
| MMP7 | 204259_at | 2.69 | 6.22 | 1.04E‐12 | 3.53 | ↑ | 0.22 | 0.17 | 0.17 | 0.01 | |
| MMP8 | 207329_at | 2.07 | 2.05 | 2.70E‐01 | −0.01 | 0.19 | 0.15 | 0.12 | 0.02 | ||
| MMP9 | 203936_s_at | 5.02 | 7.19 | 2.06E‐04 | 2.17 | ↑ | * | 0.58 | 0.58 | 0.42 | −0.03 |
| MMP10 | 205680_at | 2.49 | 3.87 | 2.38E‐26 | 1.38 | ↑ | 0.30 | 0.08 | 0.03 | 0.02 | |
| MMP11 | 203878_s_at | 4.27 | 5.77 | 2.34E‐13 | 1.50 | ↑ | * | 0.32 | 0.50 | 0.54 | −0.14 |
| MMP12 | 204580_at | 9.43 | 10.34 | 1.50E‐01 | 0.91 | 0.36 | 0.33 | 0.22 | −0.01 | ||
| MMP13 | 205959_at | 2.41 | 2.41 | 4.23E‐04 | 0.00 | 0.31 | 0.28 | 0.27 | 0.05 | ||
| MMP14 | 202827_s_at | 2.88 | 5.38 | 1.09E‐40 | 2.50 | ↑ | * | 0.51 | 0.56 | 0.44 | 0.05 |
| MMP15 | 203365_s_at | 7.18 | 6.60 | 8.22E‐02 | −0.58 | −0.31 | −0.27 | −0.26 | 0.06 | ||
| MMP16 | 207012_at | 2.36 | 2.33 | 1.98E‐01 | −0.03 | −0.06 | −0.08 | −0.09 | 0.04 | ||
| MMP17 | 206234_s_at | 2.34 | 2.34 | 2.04E‐01 | 0.00 | 0.03 | 0.10 | −0.02 | −0.03 | ||
| MMP19 | 204575_s_at | 3.15 | 3.17 | 6.37E‐02 | 0.02 | 0.55 | 0.60 | 0.51 | 0.01 | ||
| MMP20 | 207599_at | 2.50 | 2.47 | 6.83E‐01 | −0.03 | 0.02 | 0.12 | 0.07 | −0.03 | ||
| MMP21 | 1552592_at | 2.62 | 2.58 | 1.68E‐01 | −0.04 | −0.21 | −0.29 | −0.17 | 0.05 | ||
| MMP23A/MMP23B | 207118_s_at | 2.01 | 2.01 | 3.35E‐01 | −0.01 | 0.12 | 0.22 | 0.17 | 0.00 | ||
| MMP24 | 213171_s_at | 2.92 | 2.91 | 8.90E‐01 | −0.01 | 0.02 | −0.02 | 0.02 | 0.00 | ||
| MMP25 | 207890_s_at | 2.97 | 2.96 | 9.23E‐01 | −0.01 | 0.37 | 0.21 | 0.14 | 0.08 | ||
| MMP26 | 220541_at | 2.06 | 2.05 | 2.50E‐01 | −0.01 | −0.02 | −0.01 | −0.08 | −0.06 | ||
| MMP27 | 220783_at | 2.17 | 2.15 | 2.08E‐02 | −0.02 | −0.13 | −0.13 | −0.07 | 0.06 | ||
| MMP28 | 239272_at | 8.11 | 3.80 | 2.38E‐10 | −4.31 | ↓ | −0.05 | 0.17 | −0.02 | 0.12 | |
Five of the nine matrix metalloproteinases, marked with an asterisk, are differently regulated from normal to tumour tissue and correlate significantly with at least one of the TIMPs. Median log2 expression values were normalized around zero. Genes significantly regulated are marked with an arrow.