Table 4.
Pearson correlation analysis of 13 genes correlating with the TIMP‐1 transcript
| Gene | Gene name | Median log2 | p‐value | log2 ratio | Pearson correlation coefficient | ||
|---|---|---|---|---|---|---|---|
| Normal | Tumour | TIMP‐1 201666_at | |||||
| BGN | biglycan | 4.9 | 6.7 | 1.34E‐07 | 1.8 | ↑ | 0.648 |
| biglycan/serologically defined colon cancer | |||||||
| BGN/SDCCAG33 | antigen 33 | 4.2 | 6.8 | 8.80E‐07 | 2.6 | ↑ | 0.660 |
| COL1A1 | collagen, type I, alpha 1 | 8.1 | 11.2 | 5.30E‐10 | 3.1 | ↑ | 0.653 |
| COL6A2 | collagen, type VI, alpha 2 | 7.0 | 8.8 | 3.21E‐03 | 1.8 | ↑ | 0.652 |
| SPON2 | spondin 2 | 5.8 | 7.8 | 4.12E‐07 | 2.0 | ↑ | 0.609 |
| LOXL2 | lysyl oxidase‐like 2 | 5.5 | 7.5 | 1.88E‐11 | 2.1 | ↑ | 0.653 |
| TGFB1 | transforming growth factor, beta 1 | 2.9 | 5.2 | 4.81E‐24 | 2.3 | ↑ | 0.631 |
| INHBA | inhibin, beta A (activin A) | 3.2 | 6.1 | 2.09E‐13 | 2.9 | ↑ | 0.711 |
| PLAU | urokinase plasminogen activator | 4.6 | 7.3 | 1.08E‐05 | 2.7 | ↑ | 0.613 |
| TNFAIP6 | tumour necrosis factor, alpha‐induced protein 6 | 3.2 | 4.4 | 1.47E‐04 | 1.2 | ↑ | 0.687 |
| NNMT | nicotinamide N‐methyltransferase | 4.9 | 6.8 | 4.23E‐03 | 2.0 | ↑ | 0.646 |
| ICAM1 | intercellular adhesion molecule 1 (CD54) | 3.8 | 5.7 | 9.75E‐05 | 1.9 | ↑ | 0.637 |
| THY1 | Thy‐1 cell surface antigen | 4.8 | 6.8 | 2.82E‐06 | 2.0 | ↑ | 0.627 |
Median log2 expression values were normalized around zero. All are significantly up‐regulated (arrow) in tumour tissue compared to normal mucosa.