Table 3.
Differentially expressed genes (n=45) between stage 4S and [1yr−] stage 4 neuroblastoma
| Symbol | Title | Accession number | Loc chrom | Fold change |
|---|---|---|---|---|
| Immune response | ||||
| IFNG | Interferon gamma | NM_000619 | 12q14 | −1.6 |
| SERPINI1 | Serine protein 1 | NM_005025 | 3q26.1 | −1.6 |
| RAG2 | Recombination activating gene | NM_000536 | 11p13 | −1.8 |
| BC039725 | Protein with an immunoglobulin (Ig) domain | BC039725 | – | −2.0 |
| BRDG1 | B cell receptor downstream signaling 1 | NM_012108 | 4q13.2 | −3.0 |
| Transcription factors | ||||
| NFYA | Nuclear transcription factor Y alpha | NM_002505 | 6p21.3 | 2.5 |
| PBX3 | Pre‐B‐cell leukemia transcription factor 3 | NM_006195 | 9q33–q34 | 2.1 |
| Signaling | ||||
| LOC123722 | Hypothetical protein | ENST00000334574 | 15q25.2 | 2.8 |
| PTP4A1 | Pr. tyrosine phosphatase type IVA member1 | NM_003463 | 6q12 | 2.0 |
| TNFAIP2 | Tumor necrosis factor alpha‐induced protein2 | NM_006291 | 14q32 | −1.6 |
| AP4E1 | Adaptor‐related pr. complex 4 subunit epsilon1 | CR749604 | 15q21.2 | −1.8 |
| FLJ35220 | Member of the endonuclease V family | A_23_P32433 | 17q25.3 | −1.8 |
| RASGRP1 | RAS guanyl releasing protein | NM_005739 | 15q15 | −1.8 |
| SLC36A2 | Solute carrier family 36 member 2 | NM_181776 | – | −1.9 |
| CX62 | Connexin 62 | NM_032602 | 6q15–q16 | −2.0 |
| PART1 | Prostate androgen‐regulated transcript 1 | NM_016590 | 5q12.1 | −2.2 |
| EGFL6 | EGF‐like‐domain, multiple 6 | NM_015507 | Xp22 | −2.4 |
| Metabolism | ||||
| DHRS8 | Dehydrogenase/reductase 2(RetSDR2) | NM_016245 | 4q22.1 | 2.3 |
| GPR133 | G protein‐coupled receptor 133 | NM_198827 | 12q24.33 | 1.7 |
| A_23_P61288 | – | A_23_P61288 | – | −1.6 |
| BOC | Brother of CDO | NM_033254 | 3q13.2 | −1.8 |
| KLRF1 | Killer cell lectin‐like receptor F member 1 | NM_016523 | 12p12.3–13.2 | −2.0 |
| Muscle development | ||||
| CFL2 | Cofilin 2 | NM_021914 | 14q12 | 1.8 |
| CASQ2 | Calsequestrin 2 | NM_001232 | 1p13.3–p11 | −1.6 |
| ITGA7 | Integrin alpha 7 | NM_002206 | 12q13 | −1.8 |
| MYL1 | Myosin, light polypeptide 1 | NM_079422 | 2q33–q34 | −2.0 |
| Synaptic transmission | ||||
| GABRR2 | Gamma‐aminobutyric acid receptor rho 2 | NM_002043 | 6q14–q21 | 4.5 |
| KCNMB1 | b1subunit calcium‐activated K+ channel | NM_004137 | 5q34 | −1.5 |
| Unknown function | ||||
| A_23_P15851 | Unknown function | A_23_P158513 | – | 2.5 |
| BTNL8 | Similarity with butyrophylin Btn1a1 | NM_024850 | 5q35.3 | 2.4 |
| MGC50721 | Hypothetical protein | NM_173806 | 16p12.1 | 2.0 |
| X102 | X102 protein | ENST00000327992 | 15q11.2 | 1.4 |
| C6orf165 | Chromosome 6 open reading frame 165 | NM_178823 | 6q15 | −1.6 |
| FLJ36198 | Hypothetical protein | NM_173801 | 11q12.1 | −1.6 |
| MGC26816 | Hypothetical protein | NM_152613 | 22q13.2 | −1.6 |
| FLJ20825 | Unknown function | AK000832 | 20q13.33 | −1.6 |
| C9orf52 | Chromosome 9 open reading frame 52 | NM_152574 | 9p22.3 | −1.7 |
| R7BP | Similarity with D13Bxg1146e | BX640900 | – | −1.7 |
| KIAA0125 | Hypothetical protein | NM_014792 | 14q32.33 | −1.7 |
| PRO1257 | Hypothetical protein | AF116629 | 1q24.1 | −1.7 |
| CMYA3 | Cardiomyopathy associated A3 | AL833291 | 2q24.3 | −1.7 |
| FLJ23550 | Hypothetical protein | NM_025063 | 1q24.3 | −1.8 |
| C15orf25 | Chromosome 15 open reading frame 25 | A_23_P58157 | 15q15.1 | −2.3 |
| MGC45438 | Unknown function | NM_152459 | 16p13.3 | −3.1 |
Top‐ranked genes of the stage 4S NB cluster (up‐ and down‐regulated). Genes listed are statistically significant (t‐test p‐value <0.001) as reported by BRB Array Tools after combination of the arrays within Rosetta Resolver® system for gene expression data analysis. Genes are classified by biological function, as reported in the 22K Agilent annotation. Functional annotation was performed using the Online Mendelian Inheritance in Man (OMIM). Fold change is calculated as the 4S/[1yr−] stage 4 ratio. Negative fold change means the log(Cy5 labeled [1yr−]/Cy3 labeled pool) ratio is higher than that of 4S. Underlined genes are common with those of the 4S vs non‐4S genes’ set.