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. Author manuscript; available in PMC: 2017 Jul 26.
Published in final edited form as: Front Biosci (Schol Ed). 2015 Jun 1;7:58–82. doi: 10.2741/s425

Figure 2.

Figure 2

Fisetin maintains learning and memory in AD mice. (A) Performance of the mice during the acquisition phase of the MWM test. 9 month-old AD mice failed to learn the task over the 5-day testing period whereas fisetin-treated AD mice learned to locate the submerged platform. (B) Performance of the mice during the memory phase of the MWM test. AD mice did not spend a greater than random percentage of their time in the quadrant where the submerged platform was previously located whereas fisetin-treated AD mice spent greater than random amounts of time in the platform quadrant. (C) Performance of 12 month old mice during the 2-day MWM test. Although all the mice learned to find the visible platform on day 1, the AD mice did not remember where the platform was located when it was submerged on day 2 whereas fisetin-treated AD mice did remember. (D) 12 month old AD mice spend more time in the open arm of the elevated plus maze, an indicator of disinhibition, as compared with fisetin-treated AD mice. Data represent means ± SD, n = 9–12 per group. Analysis by one-way ANOVA followed by Tukey Kramer multiple comparisons post hoc test. * p < 0.05 and ** p < 0.01 relative to control non-Tg mice. (From 18)