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. Author manuscript; available in PMC: 2017 Jul 26.
Published in final edited form as: Front Biosci (Schol Ed). 2015 Jun 1;7:58–82. doi: 10.2741/s425

Table 1.

Mechanisms of Action of Fisetin and their Potential Relevance to Neurological Diseases

Mechanism of Action Potential Disease Relevance
Antioxidant and chelating activity AD; HD; stroke; diabetes
Maintenance of GSH AD; stroke; diabetes
Neurotrophic factor signaling pathways AD; HD; depression
Regulation of the innate immune response AD; stroke; diabetes
Modulation of protein aggregation and stability AD; HD