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Fisetin is a Pan-LOX Inhibitor
| Enzyme | Source | Fisetin IC50 |
|---|---|---|
| 5-LOX | Human PBML | 0.58 μM |
| 12-LOX | Human platelets | 0.13 μM |
| 15-LOX | Rabbit reticulocytes | 0.34 μM |
| COX1 | Human platelets | >10 μM |
| COX2 | Human recombinant | >10 μM |
Dose response curves were done with fisetin under standard conditions using the indicated cell types and the IC50 values are presented.
