Table 3.

Cox Regression Analyses of Factors Associated With Overall Survival

	Univariate analyses			Multivariate analysis
Factor	HR	95% CI	P	HR	95% CI	P
Positive resection margin	2.423	1.414 – 4.153	0.001	3.360	1.741 – 6.485	< 0.001
Positive lymph nodes in relation to primary cancer	1.539	1.053 – 2.247	0.026
Disease-free interval > 12 months	1.293	0.891 – 1.877	0.176
Diameter of largest CLM ≥ 30 mm	1.564	1.106 – 2.214	0.012
CEA ≥ 4.5 ng/mL	1.288	0.919 – 1.804	0.141
RAS mutation	2.181	1.547 – 3.077	< 0.001	1.629	1.013 – 2.620	0.044
Minor pathologic response (50–100% viable tumor cells)	1.728	1.095 – 2.727	0.019	1.562	0.973 – 2.506	0.065