Figure 1.

Immunogen location on the extracellular domain of HER2. Five protein fragments covering the extracellular region of the HER2 protein were cloned and expressed as recombinant protein fragments (A). Immunogens 1–4 (residues 42–186, 236–363, 324–530, 531–626) were chosen to resemble the four domains of HER2‐ecd (B), whereas Immunogen 5 (residues 347–492) was chosen on low sequence identity to other human proteins (Lindskog et al., 2005).