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. 2009 Jan 31;3(3):238–247. doi: 10.1016/j.molonc.2009.01.003

Figure 7.

Figure 7

Location of the mapped epitopes on the HER2 structure. The locations of the five epitopes mapped (see Figure 5) are shown on the structure of HER2 (Franklin et al., 2004). The epitopes of the C‐terminal region is located on domain III and the epitopes are part of an alpha‐helical structure (epitope C2) or a loop structure in proximity of a beta‐pleated sheet structure (epitope C1), whereas the N‐terminal epitopes span over the HER2 dimerization arm (N1–N2) and residues involved in the pertuzumab binding site (N3).